Differential roles of phase I and phase II enzymes in 3 , 4 - methylendioxymethamphetamine ( MDMA ) - induced cytotoxicity
نویسندگان
چکیده
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (I.A.L, J.M, S.M.N, P.S, M.v.d.B, M.B.M.v.D). National Poisons Information Centre, National Institute for Public Health and the Environment, Bilthoven Netherlands (I.A.L, J.M). Division Intensive Care Center, University Medical Center Utrecht, Utrecht, Netherlands (J.M). DMD Fast Forward. Published on April 13, 2010 as doi:10.1124/dmd.110.032359
منابع مشابه
Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity.
Metabolism plays an important role in the toxic effects caused by 3,4-methylenedioxymethamphetamine (MDMA). Most research has focused on the involvement of CYP2D6 enzyme in MDMA bioactivation, and less is known about the contribution of other cytochrome P450 (P450) and phase II metabolism. In this study, we researched the differential roles of phase I P450 enzymes CYP1A2, CYP3A4, and CYP2D6 and...
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تاریخ انتشار 2010